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Pulmonary hypertension complicating multiple myeloma.

TitlePulmonary hypertension complicating multiple myeloma.
Publication TypeJournal Article
Year of Publication2015
AuthorsKrishnan U, Mark TM, Niesvizky R, Sobol I
JournalPulm Circ
Volume5
Issue3
Pagination590-7
Date Published2015 Sep
ISSN2045-8932
Abstract

Pulmonary hypertension (PH) is an infrequently reported complication of multiple myeloma (MM). PH has been more commonly associated with amyloidosis, myeloproliferative diseases, and the POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes) syndrome. PH in MM is typically mild to moderate and may be secondary to a variety of conditions, which include left ventricular dysfunction, high-output cardiac failure, chronic kidney disease, treatment-related toxicities, and precapillary involvement. We describe 3 patients with MM and severe PH. Each patient underwent right heart catheterization. All patients demonstrated elevated pulmonary pressures, transpulmonary gradients, and pulmonary vascular resistance. Each patient was ultimately treated with pulmonary vasodilator therapy with improvement in cardiopulmonary symptoms. Additional studies are needed to define the prevalence, prognosis, and pathogenesis of PH in this complex population and to help clarify who may benefit from targeted PH therapy.

DOI10.1086/682430
Alternate JournalPulm Circ
PubMed ID26401262
PubMed Central IDPMC4556512